Modeling elastic lamina buckling in the unloaded aortic media

Mathematical modeling of the thoracic aorta is important for detecting extraordinary and unusual stress or strain distributions hypertensive aortic wall, even in early stages, understanding development progression various cardiovascular diseases. In a freshly isolated media, which mainly comprises elastic laminas (ELs) smooth muscle layers (SMLs), circumferential EL waviness longitudinal undulation are often observed because buckling ELs, closely associated with residual stresses ELs SMLs wall. However, mechanism underlying specific mechanical interactions between SML remains unclear. We hypothesized that likely formed by superposition along axis. Hence, series numerical simulations were conducted based on design experiments approach implementing stresses. identified prestress initially administered to axial directions, predefined internodal gap, couples SML, essential parameters computationally reconstruct at an unloaded state. addition, balance assigned prestresses directions crucial successful representation structural media. Although further study required, we have verified our hypothesis reasonable current work. Moreover, information obtained here will greatly help improve roles medial wall vitro vivo states, while simultaneously providing basis more sophisticated computational aorta.